A population based standard AIF. The bolus arrival of the AIF is adjusted to the data labeled as ‘Dynamic Series’. The adjustment is made based on an average curve from the "Dynamic Series''. The region in which the curve is averaged is:
- The supplied mask or
- The entire image if no mask is supplied.
To find the best bolus arrival time (BAT) an extensive search is performed with a time step given in the UI of the node. The merit function on which the best arrival time is based on is a fit to the Kety/Extended Kety model. The fit is performed for a maximum duration after the bolus arrival as indicated in the settings.
The node produces an AIF [mM] that is matched to the bolus arrival of the dynamic data. In addition, bolus arrival time and frame number are also accessible as outputs. These are useful when defining the baseline signal of a DCE-MRI scan.
Input dynamic series.
Type: Image4DFloat, Required, Single
Input mask. This mask defines the region which is averaged to create the AIF.
Type: Image4DBool, Optional, Single
The bolus arrival time.
The bolus arrival frame.
Peak amplitude, A1, [mM] Number
The amplitude of the main peak
Peak width, Sigma1, [min] Number
The width (standard deviation) of the main peak
Peak time, T1, [min] Number
The time at the center of the main peak
Recirculation peak amplitude, A2, [mM] Number
The amplitude of the recirculation peak
Recirculation peak width, Sigma2, [mM] Number
The width (standard deviation) of the recirculation peak
Reciruclation peak time, T2, [min] Number
The time at the center of the recirculation peak
Tail amplitude, Alpha, [mM] Number
The amplitude of the concentration in the tail.
Tail drop-off, Beta, [min⁻¹] Number
The rate with which the tail concentration drops of.
Tail raise, s, [min⁻¹] Number
The speed with which the tails raises at the arrival of the bolus.
Tail delay time, tau, [min] Number
The tail raise delay.
Large vessel Hematocrit, Hct Number
Search timestep [s] Number
The BAT search time step.
Duration of fit [min] Number
The duration (after bolus arrival) during which the fit should be performed.
Fitting model Selection
The model used in the fitting.
Values: Normal, Extended
- Parker GJ, Roberts C, Macdonald A, et al. Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magn Reson Med 2006;56:993–1000.
- Murase K. Efficient method for calculating kinetic parameters using T1-weighted dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med 2004;51:858–862
Keywords: AIF, Kety, DCE, Parker, BAT, bolus, arrival
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